Lasers have been used in dentistry for diagnosis and therapeutic purposes for more than 30 years, and are an indisputable in any modern dental surgery. The use of lasers enables new treatment methods to be employed in order to meaningfully supplement traditional therapies. The purpose is to overview the use of lasers as use widely. Objective: The aim of this review is to summarize the role of lasers in different oral and maxillofacial diseases by review of literatures. Oral and maxillofacial surgery is a vast branch of dentistry which includes procedures ranging from simple extraction to pathologies of both hard and soft-tissues. Based on extensive review of literature, certain conclusion can be made regarding the use of lasers. Material and methods: A search for literature on the effect of laser treatment in various oral conditions was done. A comprehensive search to identify all relevant studies, within the parameters of the study being a PubMed indexed review, published in English between till 2015 was undertaken. A wide range of databases and other sources for the identification of relevant studies were explored.